Abstract | INTRODUCTION:
Prostate cancer metastatic to bone is a cause of significant morbidity and mortality. Bone pain and other skeletal events negatively impact the quality of life in patients who might otherwise be functioning well. As such, there has been intense interest in the development of strategies and pharmaceuticals to address this problem. AREAS COVERED: EXPERT OPINION:
Radium-223 is the first radiopharmaceutical with an overall survival benefit approved for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastasis and no known visceral metastatic disease. The additional benefit of clinically significant improved overall survival should lead to exploration of whether this agent can be used earlier in the treatment algorithm or combined with chemotherapy or androgen deprivation therapy. An individualized approach needs to be tailored to each patient based on their overall symptoms, disease burden, hematologic profile and goals of care.
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Authors | Oladapo Yeku, Susan F Slovin |
Journal | Expert opinion on drug metabolism & toxicology
(Expert Opin Drug Metab Toxicol)
Vol. 11
Issue 5
Pg. 843-9
(May 2015)
ISSN: 1744-7607 [Electronic] England |
PMID | 25740232
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Radioisotopes
- radium Ra 223 dichloride
- Radium
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Topics |
- Animals
- Antineoplastic Agents
(pharmacokinetics, therapeutic use)
- Bone Neoplasms
(drug therapy, secondary)
- Humans
- Male
- Precision Medicine
- Prostatic Neoplasms, Castration-Resistant
(drug therapy, pathology)
- Quality of Life
- Radioisotopes
(pharmacokinetics, therapeutic use)
- Radium
(pharmacokinetics, therapeutic use)
- Survival Rate
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