Complex interaction of deferasirox and Pythium insidiosum: iron-dependent attenuation of growth in vitro and immunotherapy-like enhancement of immune responses in vivo.

Abstract

Pythium insidiosum iron acquisition mechanisms are unknown. We previously showed that the iron chelator deferasirox had weak activity in vitro and in rabbits with experimental pythiosis. Here we show that deferasirox causes damage to P. insidiosum hyphae in vitro, but that activity is diminished in the presence of exogenous iron. The tissue activity of the proinflammatory enzyme adenosine deaminase and the histological pattern observed in pythiosis lesions of rabbits treated with deferasirox were similar to the ones in animals treated with immunotherapy.

• Authors: Régis A Zanette, Paula E R Bitencourt, Dimitrios P Kontoyiannis, Rafael A Fighera, Mariana M Flores, Glaucia D Kommers, Priscila S Silva, Aline Ludwig, Maria B Moretto, Sydney H Alves, Janio M Santurio
• Journal: PloS one (PLoS One) Vol. 10 Issue 3 Pg. e0118932 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 25738758 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzoates
• Iron Chelating Agents
• Triazoles
• Iron
• Deferasirox

Topics

• Animals
• Benzoates (pharmacology, therapeutic use)
• Deferasirox
• Hyphae (drug effects, growth & development)
• Immunomodulation (drug effects)
• Immunotherapy
• Iron (metabolism, pharmacology)
• Iron Chelating Agents (pharmacology, therapeutic use)
• Pythiosis (drug therapy, immunology, therapy)
• Pythium (drug effects, growth & development, physiology)
• Rabbits
• Triazoles (pharmacology, therapeutic use)