Abstract | BACKGROUND: OBJECTIVES: PATIENTS AND METHODS: In a collaborative work with Mario-Negro institute of pharmacological research in Bergamo-Italy, we registered the clinical and laboratory data, collected the serum samples, and transferred the samples to the laboratories. Serum samples were taken before the start of plasmapheresis or at least 15 days after the final exchange. RESULTS: We recruited 40 patients (14 males and 26 females) with the mean age of 46.12 ± 17.26 years. The mean activity of ADAMTS13 was 34.58% ± 21.83%. Two patients had inhibitory antibodies against ADAMTS13 with profound deficiency of ADAMTS13 activity (< 6%). Infectious diseases were the most common underlying condition, followed by systemic lupus erythematous. CONCLUSIONS: Majority of patients had an underlying condition and had various ADAMTS13 activity. The presence of inhibiting antibodies and accompanied complete deficiency of ADAMTS13 activity is an indicator of severity.
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Authors | Mohammadreza Ardalan, Parisa Rezaeifar |
Journal | Nephro-urology monthly
(Nephrourol Mon)
Vol. 6
Issue 6
Pg. e18900
(Nov 2014)
ISSN: 2251-7006 [Print] Netherlands |
PMID | 25738110
(Publication Type: Journal Article)
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