A non-opioid pathway for dynorphin-caused spinal cord injury in rats.

Abstract

Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.

• Authors: Yu Chen, Liangbi Xiang, Jun Liu, Dapeng Zhou, Hailong Yu, Qi Wang, Wenfeng Han, Mingming Guo
• Journal: Neural regeneration research (Neural Regen Res) Vol. 7 Issue 11 Pg. 815-20 (Apr 15 2012) ISSN: 1673-5374 [Print] India
• PMID: 25737707 (Publication Type: Journal Article)