Abstract | OBJECTIVE: METHODS: Axonal excitability measurement and nerve ultrasound were performed in the median nerve of 33 patients with POEMS syndrome. Serum VEGF levels were measured by ELISA. RESULTS: Compared with normal subjects (n=87), POEMS patients showed longer strength-duration time constant, fanning-out of threshold electrotonus curves, and greater threshold changes in a hyperpolarizing current-threshold relationship. Nerve ultrasound showed significant enlargement in POEMS patients. Serum VEGF levels and the extent of nerve edema partly correlated with nerve conduction slowing, as well as persistent sodium currents and inward rectification. CONCLUSIONS: In POEMS syndrome, patterns of changes in excitability properties could suggest increased persistent sodium currents, and impaired potassium and inward rectifying channels. The findings were not consistent with depolarization due to nerve edema and compression ischemia. SIGNIFICANCE:
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Authors | Satsuki Mitsuma, Sonoko Misawa, Kazumoto Shibuya, Sagiri Isose, Yukari Sekiguchi, Yuta Iwai, Minako Beppu, Keisuke Watanabe, Hiroshi Amino, Satoshi Kuwabara |
Journal | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
(Clin Neurophysiol)
Vol. 126
Issue 10
Pg. 2014-8
(Oct 2015)
ISSN: 1872-8952 [Electronic] Netherlands |
PMID | 25735476
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
Topics |
- Adult
- Aged
- Axons
(physiology)
- Edema
(diagnosis, physiopathology)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Neural Conduction
(physiology)
- POEMS Syndrome
(diagnosis, physiopathology)
- Prospective Studies
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