Abstract |
In order to explore the association between cadherin 13 (CDH13) gene promoter methylation and lung carcinoma (LC) risk, we carried out a meta-analysis with searching of PubMed, Web of Science. Ultimately, 17 articles were identified and analysised by STATA 12.0 software. Overall, we found a significant relationship between CDH13 promoter methylation and LC risk (odds ratio=6.98, 95% confidence interval: 4.21-11.56, p<0.001). Subgroup analyses further revealed that LC risk was increased for individuals carrying the methylated CDH13 compared with those with unmethylated CDH13. Hence, our study identified a strong association between CDH13 gene promoter methylation and LC and highlighted a promising potential for CDH13 methylation in LC risk prediction.
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Authors | Yun-Hua Zhong, Hao Peng, Hong-Zhong Cheng, Ping Wang |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 16
Issue 3
Pg. 1139-43
( 2015)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 25735345
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Cadherins
(genetics)
- DNA Methylation
- Humans
- Lung Neoplasms
(diagnosis, genetics)
- Meta-Analysis as Topic
- Prognosis
- Promoter Regions, Genetic
(genetics)
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