Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus.

Abstract

The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥ 256 to 16 to 64 μg/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.

• Authors: Vincent Dubée, Daria Soroka, Mélanie Cortes, Anne-Laure Lefebvre, Laurent Gutmann, Jean-Emmanuel Hugonnet, Michel Arthur, Jean-Luc Mainardi
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 5 Pg. 2938-41 (May 2015) ISSN: 1098-6596 [Electronic] United States
• PMID: 25733512 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• Azabicyclo Compounds
• Cephalosporins
• T 91825
• beta-Lactamase Inhibitors
• avibactam
• beta-Lactamases

Topics

• Azabicyclo Compounds (pharmacology)
• Cephalosporins (pharmacology)
• Mycobacterium (drug effects, enzymology)
• Mycobacterium tuberculosis (drug effects, enzymology)
• beta-Lactamase Inhibitors (pharmacology)
• beta-Lactamases (metabolism)