Association of anti-RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis.
|
| Abstract |
Patients with systemic sclerosis (SSc) have an increased risk of malignancy compared with the general population. Recently, SSc patients with anti-RNA polymerase III antibody have been reported to have an increased risk of malignancy as compared with those with other disease-specific autoantibodies in US, European and Australian populations. Therefore, we studied the relationship between disease-specific autoantibodies and malignancy in 261 Japanese SSc patients. The prevalence of malignancy was significantly higher in patients with anti-RNA polymerase III antibody (7/22, 31.8%) than in those with anti-topoisomerase I antibody (2/82, 2.4%) and in those with anticentromere antibody (8/137, 5.8%). Importantly, among seven patients with anti-RNA polymerase III antibody and malignancy, three patients (42.9%) developed malignancy from 6 months before to 12 months after SSc onset. Thus, malignancy complication in Japanese SSc patients with anti-RNA polymerase III antibody is as high as that in other races, suggesting that SSc patients with anti-RNA polymerase III antibody share the same pathological process among different ethnic groups.
|
|---|---|
| Authors | Ryosuke Saigusa, Yoshihide Asano, Kouki Nakamura, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Tetsuo Toyama, Takashi Taniguchi, Shinji Noda, Naohiko Aozasa, Kaname Akamata, Hayakazu Sumida, Miki Miyazaki, Zenshiro Tamaki, Koichi Yanaba, Yoshihiro Kuwano, Shinichi Sato |
| Journal | The Journal of dermatology (J Dermatol) Vol. 42 Issue 5 Pg. 524-7 (May 2015) ISSN: 1346-8138 [Electronic] England |
| PMID | 25720827 (Publication Type: Journal Article) |
| Copyright | © 2015 Japanese Dermatological Association. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!