Evaluation of the performance of the insulin-like growth factor-binding protein-1/alpha-fetoprotein test in diagnosing ruptured fetal membranes in pregnant women.

Abstract

OBJECTIVE:

The objective of this study was to evaluate the efficacy of IGFBP-1/AFP (insulin-like growth factor-binding protein-1/alpha-fetoprotein) immunoassay (Amnioquick Duo+) in diagnosing rupture of membranes (ROM).

STUDY DESIGN:

A prospective, observational study was performed in pregnant women with a history of fluid leakage from the vagina. The IGFBP-1/AFP immunoassay and conventional methods were used to diagnose ROM. The obstetricians were blinded to the results of the IGFBP-1/AFP immunoassay. The diagnosis of ROM was finally confirmed by reviewing the medical records after delivery.

RESULT:

One hundred patients were recruited into this study. The mean gestational age was 37.6 weeks (range 25 to 41 weeks). Twenty-six percent were preterm and 74% were at term. IGFBP-1/AFP immunoassay had a sensitivity of 94.1%, specificity of 87.5%, positive predictive value of 97.5%, negative predictive value of 73.7% and accuracy of 93% in diagnosing ROM.

CONCLUSION:

IGFBP-1/AFP immunoassay is a rapid immunoassay test for diagnosing ROM with a high sensitivity and specificity. This test can be used as an alternative method for diagnosis of ROM.

• Authors: P Ruanphoo, V Phupong
• Journal: Journal of perinatology : official journal of the California Perinatal Association (J Perinatol) Vol. 35 Issue 8 Pg. 558-60 (Aug 2015) ISSN: 1476-5543 [Electronic] United States
• PMID: 25719545 (Publication Type: Journal Article, Observational Study, Validation Study)

Chemical References

• Insulin-Like Growth Factor Binding Protein 1
• alpha-Fetoproteins

Topics

• Adult
• Amniotic Fluid (metabolism)
• Delivery, Obstetric
• Extraembryonic Membranes
• Female
• Fetal Membranes, Premature Rupture (diagnosis)
• Gestational Age
• Humans
• Infant, Newborn
• Insulin-Like Growth Factor Binding Protein 1 (analysis)
• Pregnancy
• Prospective Studies
• Sensitivity and Specificity
• Term Birth
• Thailand
• Young Adult
• alpha-Fetoproteins (analysis)