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[Tardive dyskinesia in patients with schizophrenia treated with olanzapine - results from a 20-month, prospective, open study under naturalistic conditions].

AbstractOBJECTIVES:
The objective of the study was to assess the prevalence and incidence of tardive dyskinesia in patients treated with olanzapine during the follow-up period of 20 months.
METHODS:
It was a prospective, observational, non-interventional study under naturalistic conditions, without a control group. The evaluation of the severity and presence of tardive dyskinesia was performed with the Abnormal Involuntary Movement Scale and research criteria by Schooler and Kane.
RESULTS:
The study included 573 patients (woman 43,3%) with the diagnosis of schizophrenia (ICD-10), the mean age of 41.8 (± 12) years. The mean dose of olanzapine was 15.9 (± 4.2) mg. The prevalence of tardive dyskinesia was 16.4%. The cumulative incidence assessed in the group of 479 patients was 6.47%. The annual incidence was 3.9%. An increased risk of tardive dyskinesia was observed in smokers - RR of 1.99 (CI 0.88-4.49), those taking higher doses of olanzapine 1.57 (CI 0.91-2.7) and in those who used polytherapy: 3.55 (CI 1.43-8.82). Only in the case of polytherapy a multidimensional analysis confirmed that this factor had a significant influence on the risk of tardive dyskinesia (p=0.006).
CONCLUSIONS:
The study demonstrated high (16,4%) prevalence of tardive dyskinesia, and the annual incidence (3,9%) comparable to the results of a meta-analysis by Corell et al. In the case of olanzapine in monotherapy the annual incidence was lower (1.96%) but the use of antipsychotics in polytherapy more than tripled the risk of tardive dyskinesia.
AuthorsTomasz Szafrański
JournalPsychiatria polska (Psychiatr Pol) 2014 Nov-Dec Vol. 48 Issue 6 Pg. 1155-65 ISSN: 0033-2674 [Print] Poland
Vernacular TitlePóźne dyskinezy wśród chorych na schizofrenię leczonych olanzapiną - wyniki prospektywnego, 20-miesięcznego, otwartego badania w warunkach naturalistycznych.
PMID25717485 (Publication Type: Journal Article, Observational Study)
Chemical References
  • Antipsychotic Agents
  • Benzodiazepines
  • Olanzapine
Topics
  • Adult
  • Antipsychotic Agents (administration & dosage, adverse effects)
  • Benzodiazepines (administration & dosage, adverse effects)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Dyskinesia, Drug-Induced (epidemiology)
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Olanzapine
  • Prevalence
  • Prospective Studies
  • Schizophrenia (drug therapy)
  • Severity of Illness Index
  • Young Adult

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