Abstract | OBJECTIVES: The objective of the study was to assess the prevalence and incidence of tardive dyskinesia in patients treated with olanzapine during the follow-up period of 20 months. METHODS: It was a prospective, observational, non-interventional study under naturalistic conditions, without a control group. The evaluation of the severity and presence of tardive dyskinesia was performed with the Abnormal Involuntary Movement Scale and research criteria by Schooler and Kane. RESULTS: The study included 573 patients (woman 43,3%) with the diagnosis of schizophrenia (ICD-10), the mean age of 41.8 (± 12) years. The mean dose of olanzapine was 15.9 (± 4.2) mg. The prevalence of tardive dyskinesia was 16.4%. The cumulative incidence assessed in the group of 479 patients was 6.47%. The annual incidence was 3.9%. An increased risk of tardive dyskinesia was observed in smokers - RR of 1.99 (CI 0.88-4.49), those taking higher doses of olanzapine 1.57 (CI 0.91-2.7) and in those who used polytherapy: 3.55 (CI 1.43-8.82). Only in the case of polytherapy a multidimensional analysis confirmed that this factor had a significant influence on the risk of tardive dyskinesia (p=0.006). CONCLUSIONS: The study demonstrated high (16,4%) prevalence of tardive dyskinesia, and the annual incidence (3,9%) comparable to the results of a meta-analysis by Corell et al. In the case of olanzapine in monotherapy the annual incidence was lower (1.96%) but the use of antipsychotics in polytherapy more than tripled the risk of tardive dyskinesia.
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Authors | Tomasz Szafrański |
Journal | Psychiatria polska
(Psychiatr Pol)
2014 Nov-Dec
Vol. 48
Issue 6
Pg. 1155-65
ISSN: 0033-2674 [Print] Poland |
Vernacular Title | Późne dyskinezy wśród chorych na schizofrenię leczonych olanzapiną - wyniki prospektywnego, 20-miesięcznego, otwartego badania w warunkach naturalistycznych. |
PMID | 25717485
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Antipsychotic Agents
- Benzodiazepines
- Olanzapine
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Topics |
- Adult
- Antipsychotic Agents
(administration & dosage, adverse effects)
- Benzodiazepines
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Dyskinesia, Drug-Induced
(epidemiology)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Olanzapine
- Prevalence
- Prospective Studies
- Schizophrenia
(drug therapy)
- Severity of Illness Index
- Young Adult
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