[Current Topics on Vitamin D. Vitamin D and chronic kidney disease].

Abstract

CKD-MBD is a new clinical concept which defines a systemic disorder of mineral and bone metabolism as a result of CKD. Although various mineral metabolic factors are involved in its pathogenesis, alteration in vitamin D metabolism plays a crucial role among them. Vitamin D receptor activators (VDRAs), which are traditionally considered a cardinal treatment of secondary hyperparathyroidism, have attracted lots of attention for their potential pleiotropic effects through the activation of the vitamin D receptor expressed in multiple organs. In recent years, the deficiency of vitamin D in CKD patients also has received growing interest. The serum 25 (OH) D levels are considered as a useful prognostic marker, and the significances of nutritional vitamin D supplementation are reviewed from a new perspective.

• Authors: Yousuke Nakagawa, Masahiro Koizumi, Masafumi Fukagawa
• Journal: Clinical calcium (Clin Calcium) Vol. 25 Issue 3 Pg. 413-23 (Mar 2015) ISSN: 0917-5857 [Print] Japan
• PMID: 25716815 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Biomarkers
• Receptors, Calcitriol
• Vitamin D

Topics

• Animals
• Biomarkers (blood)
• Bone Diseases, Metabolic (drug therapy)
• Humans
• Receptors, Calcitriol (metabolism)
• Renal Insufficiency, Chronic (complications, diagnosis, metabolism)
• Vitamin D (metabolism, pharmacology)
• Vitamin D Deficiency (complications, metabolism)