Abstract | BACKGROUND: Oxidative stress has been implicated in the pathogenesis of many conditions, including insulin resistance and obesity. However, in vivo data concerning these relationships are scarce and conflicting. Therefore, the aim of this study was to investigate the association of oxidative stress with abdominal adiposity and insulin resistance in individuals at high cardiometabolic risk. METHODS: A total of 116 overweight/obese individuals participating in the HealthGrain and Etherpaths European Projects, having waist circumference (WC) and any other component of the metabolic syndrome, were included in this cross-sectional evaluation. 8-Isoprostane concentrations in 24-hr urine were measured as marker of oxidative stress in vivo. Baseline anthropometric and metabolic parameters were analyzed according to quartiles of 8-isoprostanes. Linear regression (LR) analysis was used to assess clinical correlates of oxidative stress. RESULTS: CONCLUSIONS:
Central obesity was independently associated with oxidative stress even in a population homogeneous for adiposity and cardiometabolic risk, whereas no relationship was observed between oxidative stress and insulin resistance.
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Authors | Giuseppina Costabile, Giuseppe Della Pepa, Lutgarda Bozzetto, Giovanni Annuzzi, Claudia Vetrani, Rosalba Giacco, Giuseppina Della Corte, Francesca Serena Conte, Lucrezia Di Marino, Angela Albarosa Rivellese |
Journal | Metabolic syndrome and related disorders
(Metab Syndr Relat Disord)
Vol. 13
Issue 4
Pg. 187-91
(May 2015)
ISSN: 1557-8518 [Electronic] United States |
PMID | 25714911
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Triglycerides
- 8-epi-prostaglandin F2alpha
- Dinoprost
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Topics |
- Abdominal Fat
- Adiposity
- Adult
- Age Factors
- Aged
- Body Weight
- Cholesterol, HDL
(blood)
- Cross-Sectional Studies
- Dinoprost
(analogs & derivatives, urine)
- Female
- Humans
- Insulin Resistance
- Male
- Metabolic Syndrome
(urine)
- Middle Aged
- Obesity
(urine)
- Overweight
(urine)
- Oxidative Stress
- Risk Assessment
- Sex Characteristics
- Triglycerides
(blood)
- Waist Circumference
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