Abstract | BACKGROUND: OBJECTIVE: The objective of the present work was to study the role of midodrine in patients with non-azotemic cirrhosis with tense ascites. METHODS: This prospective randomized double blind placebo-controlled study was conducted on 67 non azotemic inpatients with liver cirrhosis and tense ascites (52 men and 15 women; age range, 45-72). One patient declined to participate in the study, 33 patients were randomly assigned to take midodrine hydrochloride, and 33 patients were randomly assigned to take placebo. Out of 67 enrolled patients, 60 patients (30: in midodrine group; 30: in placebo group) completed the study and 6 patients lost to follow up. Patients were assessed for patients’ characteristics, history of tapping their ascetic fluid, laboratory values, and Doppler parameters before and after the study. Average 24-h urine volume was assessed before and after the start of the study. RESULTS: CONCLUSION:
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Authors | Ahmed Ali, Samar Farid, Mona Amin, Mohamed Kassem, Nouman Al-Garem |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
Vol. 61
Issue 135
Pg. 1915-24
(Oct 2014)
ISSN: 0172-6390 [Print] Greece |
PMID | 25713888
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic alpha-1 Receptor Agonists
- Midodrine
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Topics |
- Adrenergic alpha-1 Receptor Agonists
(therapeutic use)
- Aged
- Ascites
(diagnosis, drug therapy, etiology, physiopathology)
- Blood Flow Velocity
- Double-Blind Method
- Drainage
- Egypt
- Female
- Hepatic Artery
(diagnostic imaging, physiopathology)
- Humans
- Liver Circulation
- Liver Cirrhosis
(complications, diagnosis, drug therapy, physiopathology)
- Male
- Middle Aged
- Midodrine
(therapeutic use)
- Portal Vein
(diagnostic imaging, physiopathology)
- Prospective Studies
- Time Factors
- Treatment Outcome
- Ultrasonography, Doppler
- Urination
- Waist Circumference
- Weight Loss
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