Abstract |
Conscious Hartley guinea pigs were challenged with LTD4 or LTE4 aerosols. When dynamic compliance (Cdyn) decreased to 50% of its baseline value, the challenge aerosols were stopped and treatment aerosols of salbutamol, the LTD4/E4 antagonist LY171883 Na, atropine, or sodium chloride (control) were begun. After 5 min of continuous exposure to the treatment aerosol, each animal was killed and excised lung gas volume (ELGV) was measured. Salbutamol was equally effective in reversing LTD4- and LTE4-induced Cdyn changes. Aerosolized LY171883 Na was effective against both agonists, but was about threefold more potent against LTE4. In contrast, atropine was very effective in reversing LTD4-induced Cdyn changes, but produced minimal reversal when LTE4 was the challenge agent. Pulmonary gas trapping results supported these observations; ELGV values were closely correlated with 5-min Cdyn measurements for both LTD4 (r = -0.817) and LTE4 (r = -0.831). Thus, although LTD4 and LTE4 are though to act on the same or similar receptors, the pattern of pharmacologic reversal at comparable levels of airway obstruction differs for these two agonists.
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Authors | S A Silbaugh, P W Stengel, P A Pechous, W S Marshall |
Journal | The American review of respiratory disease
(Am Rev Respir Dis)
Vol. 140
Issue 3
Pg. 610-4
(Sep 1989)
ISSN: 0003-0805 [Print] United States |
PMID | 2571321
(Publication Type: Journal Article)
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Chemical References |
- Acetophenones
- Autacoids
- SRS-A
- Tetrazoles
- Leukotriene E4
- Atropine
- LY 171883
- Albuterol
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Topics |
- Acetophenones
(pharmacology)
- Airway Resistance
(drug effects)
- Albuterol
(pharmacology)
- Animals
- Atropine
(pharmacology)
- Autacoids
(antagonists & inhibitors)
- Bronchi
(drug effects, physiology)
- Guinea Pigs
- Leukotriene E4
- Lung Compliance
(drug effects)
- Lung Volume Measurements
- Male
- Respiration
(drug effects)
- SRS-A
(analogs & derivatives, pharmacology)
- Tetrazoles
(pharmacology)
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