Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia.
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| Abstract |
Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. Here we show, in 2 populations from Burkina Faso (2007-2008), that HbS is associated with a 70% reduction of harboring P. falciparum parasitemia at the heterozygous state (odds ratio [OR] for AS vs AA, 0.27; 95% confidence interval [CI], .11-.66; P = .004). There is no evidence of protection for HbC in the heterozygous state (OR for AC vs AA, 1.49; 95% CI, .69-3.21; P = .31), whereas protection even higher than that observed with AS is observed in the homozygous and double heterozygous states (OR for CC + SC vs AA, 0.04; 95% CI, .01-.29; P = .002). The abnormal display of parasite-adhesive molecules on the surface of HbS and HbC infected erythrocytes, disrupting the pathogenic process of sequestration, might displace the parasite from the deep to the peripheral circulation, promoting its elimination at the spleen level.
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| Authors | Valentina D Mangano, Youssouf Kabore, Edith C Bougouma, Federica Verra, Nuno Sepulveda, Cyrille Bisseye, Federica Santolamazza, Pamela Avellino, Alfred B Tiono, Amidou Diarra, Issa Nebie, Kirk A Rockett, Sodiomon B Sirima, David Modiano, MalariaGEN Consortium |
| Journal | The Journal of infectious diseases (J Infect Dis) Vol. 212 Issue 4 Pg. 626-34 (Aug 15 2015) ISSN: 1537-6613 [Electronic] United States |
| PMID | 25712976 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. |
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