Combining endometrium sampling device and SurePath preparation to screen for endometrial carcinoma: a validation study.

Abstract

BACKGROUND:

The aim of this study was to compare specimen adequacy of SAP-1 provided for cytology with that of dilation and curettage (D & C) or hysteroscopy for histology, and evaluate the accuracy of combining endometrium sampling by SAP-1 and liquid-based cytology using SurePath preparation for screening endometrial carcinoma and its precursor.

METHODS:

Endometrial specimens from women (n = 1514) with risk factors were obtained using an SAP-1 device for cytological analysis; histological samples were obtained from 375 of these women who underwent D & C or hysteroscopy. Cytological specimens were prepared to liquid-based smear using SurePath technology and stained by Papanicolaou. Histological samples were processed in routine pathology and stained by hematoxylin and eosin.

RESULTS:

Adequate specimens for cytology were obtained from 1458/1541 patients (96.3%), while adequate samples for pathology were obtained from 285/375 patients (76%). However, for postmenopausal women, 1006 of 1045 cytology (86.3%) were adequate, 153 of 238 histology (64.3%) were adequate, it was easier to collect cytological specimens than histological specimens (P < 0.05). The accuracy of endometrial cytology for detecting endometrial carcinoma and its precursor was 92.4% (sensitivity, 73%; specificity, 95.8%; positive predictive value, 75%; and negative predictive value, 95.3%).

CONCLUSIONS:

Endometrial cytology using SAP-1 sampling and SurePath preparation may be a reliable approach for screening patients with endometrial carcinoma and its precursor.

• Authors: Jia Wen, Rui Chen, Jian Zhao, Yin Dong, Xi Yang, Qin-Ping Liao
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 128 Issue 5 Pg. 648-53 (Mar 05 2015) ISSN: 2542-5641 [Electronic] China
• PMID: 25698198 (Publication Type: Journal Article)

Topics

• Adult
• Biopsy (methods)
• Cytodiagnosis (methods)
• Endometrial Hyperplasia (diagnosis)
• Endometrial Neoplasms (diagnosis)
• Female
• Humans
• Specimen Handling (methods)