[Hepatoprotective activity of betulonic acid amides containing a piperidine or pyrrolidine nitroxide moiety].

Abstract

Betulonic acid amides containing a nitroxyl radical moiety possess antiholestatic effects in mice. Introduction ofpiperidine nitroxide moiety into lupan core increases its hepatoprotective activity. Oral administration of piperidine nitroxide derivative in dose 50 mg/kg doesn't stimulate transplanted tumor growth and raises a lifespan of mice.

• Authors: I V Sorokina, D S Baev, N A Zhukova, T G Tolstikova, A N Antimonova, N I Petrenko, E E Shul'ts, I A Grigor'ev
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) 2013 Nov-Dec Vol. 39 Issue 6 Pg. 749-52 ISSN: 0132-3423 [Print] Russia (Federation)
• PMID: 25696937 (Publication Type: Journal Article)

Chemical References

• Amides
• Nitrogen Oxides
• Piperidines
• Pyrrolidines
• betulonic acid
• piperidine
• Oleanolic Acid
• nitroxyl
• pyrrolidine

Topics

• Amides (administration & dosage, chemistry)
• Animals
• Apoptosis (drug effects)
• Carcinoma, Lewis Lung (drug therapy, pathology)
• Hepatitis (drug therapy, pathology)
• Humans
• Mice
• Nitrogen Oxides (chemistry)
• Oleanolic Acid (administration & dosage, analogs & derivatives, chemistry)
• Piperidines (administration & dosage, chemistry)
• Pyrrolidines (administration & dosage, chemistry)