Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: After a gestation period of closely supervised feasibility studies in research centers, the last 2 years have seen publication of studies testing these devices in outpatient environments, and many more such studies are ongoing. The most basic form of automation, suspension of insulin delivery for actual or predicted hypoglycemia, has been shown to be effective and well tolerated, and a first-generation device has actually reached the market. Artificial pancreas devices that actively dose insulin fall into two categories, those that dose insulin alone and those that also use glucagon to prevent and treat hypoglycemia (bihormonal artificial pancreas). Initial outpatient clinical trials have shown that both strategies can improve glycemic management in comparison with patient-controlled insulin pump therapy, but only the bihormonal strategy has been tested without restrictions on exercise. SUMMARY:
Artificial pancreas technology has the potential to reduce acute and chronic complications of diabetes and mitigate the burden of diabetes self-management. Successful outpatient studies bring these technologies one step closer to availability for patients.
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Authors | Steven J Russell |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 22
Issue 2
Pg. 106-11
(Apr 2015)
ISSN: 1752-2978 [Electronic] England |
PMID | 25692927
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Biomarkers
- Blood Glucose
- Hypoglycemic Agents
- Insulin
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Topics |
- Ambulatory Care
- Biomarkers
- Blood Glucose
(metabolism)
- Blood Glucose Self-Monitoring
(instrumentation)
- Circadian Rhythm
- Diabetes Mellitus, Type 1
(blood, diagnosis, drug therapy)
- Diffusion of Innovation
- Equipment Design
- Humans
- Hypoglycemic Agents
(administration & dosage, adverse effects)
- Insulin
(administration & dosage, adverse effects)
- Insulin Infusion Systems
(adverse effects)
- Life Style
- Pancreas, Artificial
(adverse effects)
- Risk Factors
- Treatment Outcome
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