Abstract | OBJECTIVE: Classical neuromodulation consists of applying electrical or magnetic stimuli to the nervous system to modulate ongoing activity and connectivity. However, recently, an exciting novel neuromodulation technique was developed in which stimulation of the vagal nerve was paired with simultaneous presentation of tones, demonstrating that it reverses a tinnitus percept in noise-exposed rats. STUDY DESIGN: RESULTS: At the end of therapy, the patient experienced a significant reduction in tinnitus symptoms that lasted for 2 months after treatment. Tinnitus Handicap Inventory and Tinnitus Reaction Questionnaire were reduced by 48% and 68%, respectively. Symptoms of depression were also improved by 40%, as quantified by the Beck Depression Inventory. Three months after ending therapy, placebo stimulation was performed consisting of only tone presentation without the simultaneous electrical stimuli. This resulted in further continuation of the gradual relapse to the baseline state, without renewed improvement. CONCLUSION:
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Authors | Dirk De Ridder, Michael Kilgard, Navzer Engineer, Sven Vanneste |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 36
Issue 4
Pg. 575-80
(Apr 2015)
ISSN: 1537-4505 [Electronic] United States |
PMID | 25689839
(Publication Type: Case Reports, Clinical Trial, Journal Article)
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Topics |
- Acoustic Stimulation
(methods)
- Chronic Disease
- Humans
- Male
- Middle Aged
- Tinnitus
(therapy)
- Treatment Outcome
- Vagus Nerve Stimulation
(methods)
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