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Successful treatment of generalized granuloma annulare with adalimumab.

Abstract
We report the case of a 64 year-old woman who demonstrated resolution of recalcitrant, generalized granuloma annulare (GA) following treatment with adalimumab. After showing little response to other treatment techniques, such as steroids and a triple antibiotic regimen, the patient was started on adalimumab. Within 3 months, she showed almost complete resolution of lesions. Within 6 months, she was completely lesion-free, and remained clear following 12 months of adalimumab therapy. This case provides further evidence that tumour necrosis factor-α inhibitors may be a treatment option for patients with recalcitrant, generalized GA.
AuthorsT Mahmood, B Mansouri, A Menter
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 40 Issue 5 Pg. 537-9 (Jul 2015) ISSN: 1365-2230 [Electronic] England
PMID25688452 (Publication Type: Case Reports, Journal Article)
Copyright© 2015 British Association of Dermatologists.
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • Adalimumab
Topics
  • Adalimumab (therapeutic use)
  • Anti-Inflammatory Agents (therapeutic use)
  • Antibodies, Monoclonal (therapeutic use)
  • Female
  • Granuloma Annulare (drug therapy)
  • Humans
  • Middle Aged
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

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