Long-term Outcome of Chondrosarcoma: A Single Institutional Experience.

Abstract

PURPOSE:

The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors.

MATERIALS AND METHODS:

A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution.

RESULTS:

Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage.

CONCLUSION:

Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome.

• Authors: Srimanth Bindiganavile, Ilkyu Han, Ji Yeon Yun, Han-Soo Kim
• Journal: Cancer research and treatment (Cancer Res Treat) Vol. 47 Issue 4 Pg. 897-903 (Oct 2015) ISSN: 2005-9256 [Electronic] Korea (South)
• PMID: 25687868 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Bone Neoplasms (surgery)
• Chondrosarcoma (surgery)
• Curettage (methods)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Retrospective Studies
• Survival Analysis
• Treatment Outcome
• Young Adult