Abstract |
The clinical and laboratory characteristics of a severe form of hemorrhagic fever with renal syndrome ( HFRS) in Greece are presented. Twenty-seven patients with serologically confirmed HFRS were studied; 10 required renal dialysis, six had hemorrhagic manifestations, and four died. In patients with hemorrhagic manifestations, the platelet counts were generally less than 100,000 cells/microL. In three patients findings were compatible with disseminated intravascular coagulation. Laboratory investigation showed a consistent rise in levels of serum urea nitrogen and creatinine beginning on the fifth or sixth day of illness and reaching a maximum level between the ninth and 12th days of illness. The disease in Greece more closely resembles the Asian form of HFRS ( Korean hemorrhagic fever) than the Scandinavian form of the disease ( nephropathia epidemica) because of the high mortality rate, the occurrence of hemorrhagic manifestations, and the severity of the clinical disease.
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Authors | A Antoniadis, J W LeDuc, N Acritidis, S Alexiou-Daniel, A Kyparissi, G A Saviolakis |
Journal | Reviews of infectious diseases
(Rev Infect Dis)
1989 May-Jun
Vol. 11 Suppl 4
Pg. S891-6
ISSN: 0162-0886 [Print] United States |
PMID | 2568679
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Creatinine
(blood)
- Disseminated Intravascular Coagulation
- Greece
- Hematocrit
- Hematuria
- Hemorrhagic Fever with Renal Syndrome
(blood, epidemiology)
- Humans
- Hypoproteinemia
- Leukocyte Count
- Platelet Count
- Prothrombin Time
- Thrombocytopenia
- Urea
(blood)
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