Decreased keratocyte density and central corneal thickness in primary open-angle glaucoma patients undergoing treatment with topical prostaglandin analogues.

Abstract

PURPOSE:

To evaluate whether prostaglandin (PG) analogue use is associated with alterations in keratocyte density and central corneal thickness (CCT) in subjects with primary open-angle glaucoma (POAG).

MATERIALS AND METHODS:

Thirty-five POAG patients treated with PG analogues for >2 years and 35 control subjects without glaucoma were included in this cross-sectional study. All subjects were underwent CCT measurements using ultrasound pachymetry. Keratocyte densities of each stromal layer were determined by in vivo confocal microscopy. Student's t-test and Chi-square test were used for statistical evaluations. Correlations between keratocyte densities and CCT were analyzed using Pearson's correlation analysis.

RESULTS:

Keratocyte densities in each stromal layer were significantly lower in glaucoma patients receiving PG analogues as compared to those of controls (P < 0.001). The mean CCT was also lower in glaucoma patients (515.2 ± 18.8 μ) than control subjects (549.6 ± 21.1 μ, P < 0.001). A positive correlation between keratocyte densities in each stromal layer and CCT was observed in POAG patients.

CONCLUSIONS:

Long-term administration of topical PG analogues may adversely influence keratocyte densities and CCT. Further prospective studies are required clarify the relationship between PG analogues and their effects on the cornea.

• Authors: Sibel Kocabeyoglu, Mehmet C Mocan, Murat Irkec
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 63 Issue 1 Pg. 15-9 (Jan 2015) ISSN: 1998-3689 [Electronic] India
• PMID: 25686056 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Ophthalmic Solutions
• Prostaglandins, Synthetic

Topics

• Aged
• Aged, 80 and over
• Cornea (diagnostic imaging, pathology)
• Corneal Keratocytes (diagnostic imaging, pathology)
• Corneal Pachymetry
• Cross-Sectional Studies
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Glaucoma, Open-Angle (diagnostic imaging, drug therapy, pathology)
• Gonioscopy
• Humans
• Intraocular Pressure (drug effects)
• Male
• Microscopy, Confocal
• Middle Aged
• Ophthalmic Solutions
• Prostaglandins, Synthetic (administration & dosage)
• Retrospective Studies
• Tomography, Optical Coherence
• Treatment Outcome
• Visual Fields (physiology)