HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A continuous spinal cord stimulation model attenuates pain-related behavior in vivo following induction of a peripheral nerve injury.

AbstractOBJECTIVES:
Models that simulate clinical conditions are needed to gain an understanding of the mechanism involved during spinal cord stimulation (SCS) treatment of chronic neuropathic pain. An animal model has been developed for continuous SCS in which animals that have been injured to develop neuropathic pain behavior were allowed to carry on with regular daily activities while being stimulated for 72 hours.
MATERIAL AND METHODS:
Sprague-Dawley rats were randomized into each of six different groups (N = 10-13). Three groups included animals in which the spared nerve injury (SNI) was induced. Animals in two of these groups were implanted with a four-contact electrode in the epidural space. Animals in one of these groups received stimulation for 72 hours continuously. Three corresponding sham groups (no SNI) were included. Mechanical and cold-thermal allodynia were evaluated using von Frey filaments and acetone drops, respectively. Mean withdrawal thresholds were compared. Statistical significance was established using one-way ANOVAs followed by Holm-Sidak post hoc analysis.
RESULTS:
Continuous SCS attenuates mechanical allodynia in animals with neuropathic pain behavior. Mechanical withdrawal threshold increases significantly in SNI animals after 24 and 72 hours stimulation vs. SNI no stimulation (p = 0.007 and p < 0.001, respectively). SCS for 24 and 72 hours provides significant increase in mechanical withdrawal thresholds relative to values before stimulation (p = 0.001 and p < 0.001, respectively). Stimulation did not provide recovery to baseline values. SCS did not seem to attenuate cold-thermal allodynia.
CONCLUSION:
A continuous SCS model has been developed. Animals with neuropathic pain behavior that were continuously stimulated showed significant increase in withdrawal thresholds proportional to stimulation time.
AuthorsDana M Tilley, Ricardo Vallejo, Courtney A Kelley, Ramsin Benyamin, David L Cedeño
JournalNeuromodulation : journal of the International Neuromodulation Society (Neuromodulation) Vol. 18 Issue 3 Pg. 171-6; discussion 176 (Apr 2015) ISSN: 1525-1403 [Electronic] United States
PMID25683886 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2015 International Neuromodulation Society.
Topics
  • Animals
  • Disease Models, Animal
  • Electrodes, Implanted
  • Hyperalgesia (etiology, therapy)
  • Male
  • Neuralgia (etiology, therapy)
  • Pain Measurement
  • Pain Threshold (physiology)
  • Peripheral Nerve Injuries (complications)
  • Physical Stimulation (adverse effects)
  • Rats
  • Rats, Sprague-Dawley
  • Spinal Cord Stimulation (methods)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: