Abstract | PURPOSE: METHODS: The study sample consisted of 30 children with Marfan's syndrome, and the control group consisted of 30 untreated and matched children. For Marfan subjects, data were taken at different time points compared to treatment: at T0 (before treatment), T1 (after rapid maxillary expansion), and T2 (after mandibular advancement). For control subjects, data were taken at similar intervals, at three follow-up visits: at T0 (as a starting screening tool), T1 (after approximately 2 years), and T2 (in proximity of the peak skeletal growth). RESULTS:
Apnea-hypopnea and oxygen desaturations were significantly higher in the study group at T0 and T1 compared with control children. At T2, the values were not significant (p value 0.442 for both apnea-hypopnea index (AHI) and oxygen desaturation index (ODI)). Horizontal airway dimensions were significantly reduced, and vertical airway values were significantly increased in Marfan's syndrome at T0 and T1 but not at T2 (p values at T2: 0.071 for Phw1-Psp, 0.106 for Phw1-Psp', 0.101 for Phw2-Tb, 0.559 for UAL in male and 0.560 for UAL in female). CONCLUSIONS:
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Authors | M Taddei, N Alkhamis, T Tagariello, G D'Alessandro, E M Mariucci, G Piana |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 19
Issue 4
Pg. 1213-20
(Dec 2015)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 25682270
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Case-Control Studies
- Cephalometry
- Child
- Female
- Follow-Up Studies
- Humans
- Male
- Mandibular Advancement
(instrumentation, methods)
- Marfan Syndrome
(physiopathology, surgery)
- Orthodontic Appliance Design
- Orthodontic Appliances
- Palatal Expansion Technique
(instrumentation)
- Polysomnography
- Pulmonary Ventilation
(physiology)
- Sleep Apnea, Obstructive
(physiopathology, surgery)
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