A Novel Therapy for Laryngotracheal Stenosis: Treatment With Ethosomes Containing 5-Fluorouracil.

Abstract

PURPOSE:

The purpose of our article was to explore the effect of ethosomes containing 5-fluorouracil (5-FU) with different sizes on laryngotracheal stenosis treatment.

METHODS:

The physical characteristics of ethosomes containing 5-FU were investigated, including size, shape, and entrapment percentage. The effect of ethosomes containing 5-FU was evaluated on the airway stenosis rabbit model. The formation of fibrous/scar tissue was investigated by hematoxylin and eosin (HE) staining, and the permeation depth was observed under fluorescence microscope.

RESULTS:

The mean sizes of 5-FU ethosomes extruded by D=50 nm and D=100 nm pore were 60±10 nm and 110±13 nm, respectively. The 5-FU entrapment percentage of ethosomes was determined to be 15% (D=60±10 nm) and 32% (D=110±13 nm). After being treated by ethosomes containing 5-FU (D=60±10 nm), the fibroblast and collagenous fiber distributed sparsely in the deep scar tissue. The permeation capability of ethosomes containing 5-FU (D=60 nm) was significantly better than ethosomes (D=110 nm). Besides, the 5-FU ethosomes resulted in less stenosis than 5-FU only.

CONCLUSIONS:

Topical administration of 5-FU ethosomes may be a novel candidate therapy for laryngotracheal stenosis treatment.

• Authors: Jian Gu, Xiaohui Mao, Cong Li, Huafei Ao, Xizhi Yang
• Journal: The Annals of otology, rhinology, and laryngology (Ann Otol Rhinol Laryngol) Vol. 124 Issue 7 Pg. 561-6 (Jul 2015) ISSN: 0003-4894 [Print] United States
• PMID: 25678670 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2015.

Chemical References

• Immunosuppressive Agents
• Liposomes
• Fluorouracil

Topics

• Animals
• Disease Models, Animal
• Female
• Fluorouracil (administration & dosage, therapeutic use)
• Immunosuppressive Agents (administration & dosage)
• Laryngostenosis (complications, drug therapy)
• Liposomes
• Male
• Rabbits
• Tracheal Stenosis (complications, drug therapy)
• Treatment Outcome