Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients.
Abstract | BACKGROUND:
Liver transplantation recipients are at high risk for severe complications due to infections because of being treated with immunosuppressive drugs that affect the immune system. Vaccination for liver transplantation candidates is generally recommended before surgery, but the opportunities for vaccination prior to transplantation in pediatric candidates are often limited by severe disease conditions. METHODS: RESULTS: Seroprotection rates for measles, rubella, mumps, varicella, hepatitis B, pertussis, and Japanese encephalitis after post-transplant immunization were 44% (11/25), 70% (19/27), 48% (12/25), 32% (6/19), 83% (19/23), 87% (13/15), and 88% (7/8), respectively. Seroprotection rates for measles, rubella, mumps, and varicella after second vaccination for recipients with primary vaccine failure after first vaccination were 100% (8/8), 50% (1/2), 71% (5/7), and 50% (5/10), respectively. While four recipients contracted mumps and eight contracted varicella before immunization, one recipient developed varicella after immunization. No serious systemic adverse events were observed in vaccinated recipients. CONCLUSIONS:
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Authors | Yoshihiko Kawano, Michio Suzuki, Jun-ichi Kawada, Hiroshi Kimura, Hideya Kamei, Yasuharu Ohnishi, Yasuyuki Ono, Hiroo Uchida, Yasuhiro Ogura, Yoshinori Ito |
Journal | Vaccine
(Vaccine)
Vol. 33
Issue 12
Pg. 1440-5
(Mar 17 2015)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 25665961
(Publication Type: Journal Article)
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Copyright | Copyright © 2015. Published by Elsevier Ltd. |
Chemical References |
- Chickenpox Vaccine
- Measles-Mumps-Rubella Vaccine
- Vaccines, Attenuated
- Vaccines, Combined
- Vaccines, Inactivated
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Topics |
- Adolescent
- Age Factors
- Chickenpox
(prevention & control)
- Chickenpox Vaccine
(administration & dosage, immunology)
- Child
- Child, Preschool
- Encephalitis, Japanese
(prevention & control)
- Female
- Hepatitis B
(prevention & control)
- Humans
- Immunization Schedule
- Immunocompromised Host
- Infant
- Liver Transplantation
- Measles-Mumps-Rubella Vaccine
(administration & dosage, adverse effects, immunology)
- Mumps
(prevention & control)
- Safety
- Vaccines, Attenuated
(administration & dosage, adverse effects, immunology)
- Vaccines, Combined
(administration & dosage, adverse effects, immunology)
- Vaccines, Inactivated
(administration & dosage, adverse effects, immunology)
- Whooping Cough
(prevention & control)
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