Abstract | BACKGROUND: Idiopathic inflammatory bowel disease (IBD) and microscopic colitis (MC) are distinct entities. However, patients with intermittent episodes of IBD and MC that are encountered in a clinical setting puzzle clinicians and pathologists. This study examined whether microRNA assisted in the classification of IBD and MC. DESIGN: RESULTS: CONCLUSION: In summary, IBD and MC have distinct miR-31 expression pattern. Therefore, miR-31 might be used as a biomarker to distinguish between IBD and MC in FFPE colonic tissue. In addition, miR-31 is differentially expressed in colonic tissue between lymphocytic colitis and collagenous colitis, suggesting them of separate disease processes. Finally, patients with alternating IBD and MC episodes represent a diverse group. Among them, the majority demonstrates MC-like miR-31 expression pattern in MC phases, which seems unlikely to support the speculation of MC as an inactive form of IBD. Although the mechanisms deserve further investigation, microRNA is a potentially useful biomarker to differentiate IBD and MC.
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Authors | Chen Zhang, Zijin Zhao, Hany Osman, Rao Watson, Ilke Nalbantoglu, Jingmei Lin |
Journal | MicroRNA (Shariqah, United Arab Emirates)
(Microrna)
Vol. 3
Issue 3
Pg. 155-9
( 2014)
ISSN: 2211-5374 [Electronic] United Arab Emirates |
PMID | 25665881
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- MIRN31 microRNA, human
- MicroRNAs
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(metabolism)
- Colitis, Microscopic
(diagnosis, genetics, metabolism)
- Colitis, Ulcerative
(diagnosis, genetics, metabolism)
- Crohn Disease
(diagnosis, genetics, metabolism)
- Female
- Humans
- Male
- MicroRNAs
(genetics, metabolism)
- Middle Aged
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