Therapeutic outcomes of hematogenous vertebral osteomyelitis with instrumented surgery.

Abstract

BACKGROUND:

Patients with hematogenous vertebral osteomyelitis (HVO) occasionally require instrumentation for spinal stabilization. However, placing instrumentation in the setting of spinal infection raises concerns about recurrent infection due to bacteria adhering to the foreign material. In this study, we evaluated the therapeutic outcomes of patients with HVO who underwent instrumented surgery.

METHODS:

We conducted a retrospective chart review of adult patients with microbiologically diagnosed HVO who underwent surgical intervention in 5 tertiary care hospitals over an 8-year period.

RESULTS:

A total of 153 patients with HVO underwent surgical management for their infections. Of these 153 patients, 94 (61.4%) underwent surgical debridement alone (noninstrumented surgery) and 59 (38.6%) underwent surgical debridement and instrumentation (instrumented surgery). The median durations of antibiotic therapy were 66 and 80 days for the noninstrumentation and instrumentation groups, respectively (P = .22). Clinical outcomes were similar between the groups, including rates of infection-related death (2.1% vs 0%; P = .52), primary failure (1.1% vs 5.1%; P = .30), and recurrence (4.8% vs 6.8%; P = .72). Among the instrumentation group, there was a significant decreasing trend for recurrence according to total duration of antibiotic therapy: 22.2% (4-6 weeks), 9.1% (6-8 weeks), and 2.6% (≥ 8 weeks; P = .04). Duration of pre-instrumentation antibiotic therapy and single-stage operation (vs 2-stage operation) were not risk factors for recurrence.

CONCLUSIONS:

Spinal instrumentation in patients with HVO may be safe with pathogen-directed prolonged antibiotic therapy and should not be abandoned or delayed solely because of the risk of recurrence.

• Authors: Ki-Ho Park, Oh-Hyun Cho, Yu-Mi Lee, Chisook Moon, Seong Yeon Park, Song Mi Moon, Jung Hee Lee, Ji Seon Park, Kyung Nam Ryu, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Mi Suk Lee, Yang Soo Kim, Jun Hee Woo, In-Gyu Bae
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 60 Issue 9 Pg. 1330-8 (May 01 2015) ISSN: 1537-6591 [Electronic] United States
• PMID: 25663159 (Publication Type: Journal Article)
• Copyright: © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected].

Chemical References

• Anti-Bacterial Agents

Topics

• Aged
• Anti-Bacterial Agents (therapeutic use)
• Debridement
• Female
• Humans
• Male
• Middle Aged
• Osteomyelitis (microbiology, surgery)
• Prostheses and Implants
• Recurrence
• Republic of Korea
• Retrospective Studies
• Risk Factors
• Spinal Diseases (surgery)
• Spine (microbiology, surgery)
• Staphylococcal Infections (drug therapy, prevention & control, surgery)
• Staphylococcus aureus (isolation & purification)
• Tertiary Care Centers
• Time Factors
• Treatment Outcome