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Successful treatment of cerebral large vessel vasculitis in systemic lupus erythematosus with intravenous pulse cyclophosphamide.

Abstract
A 39-year-old woman with a six-year history of systemic lupus erythematosus (SLE) was admitted because of a prolonged high fever, discoid rash, and multiple lymphadenopathies. She also developed pericarditis, and was treated with intravenous methylprednisolone pulse therapy followed by prednisolone 50 mg daily and cyclosporine 100 mg daily. Meanwhile, she had a progressive headache, and a brain MRI revealed right pons infarction, although she did not have any abnormal neurological findings. An MRA revealed obvious irregular narrowing in the basilar, right vertebral and right posterior cerebral artery. There was no evidence of antiphospholipid syndrome. We concluded that the cause of the asymptomatic brain infarction was cerebral large vessel vasculitis associated with neuropsychiatric SLE. Intravenous cyclophosphamide pulse therapy was started, and two months later, we confirmed that the irregular arterial narrowing had markedly ameliorated.Cerebral large vessel vasculitis in neuropsychiatric SLE is very rare, and a marked amelioration has not been reported to date. Here, we present a rare case of cerebral large vessel vasculitis treated successfully with a clear visual presentation.
AuthorsR Kato, S Sumitomo, K Kawahata, K Fujio, K Yamamoto
JournalLupus (Lupus) Vol. 24 Issue 8 Pg. 880-4 (Jul 2015) ISSN: 1477-0962 [Electronic] England
PMID25661835 (Publication Type: Case Reports, Journal Article)
Copyright© The Author(s) 2015.
Chemical References
  • Immunosuppressive Agents
  • Cyclosporine
  • Cyclophosphamide
  • Prednisolone
Topics
  • Adult
  • Brain Infarction (diagnosis)
  • Cyclophosphamide (administration & dosage)
  • Cyclosporine (administration & dosage)
  • Female
  • Headache
  • Humans
  • Immunosuppressive Agents
  • Lupus Vasculitis, Central Nervous System (complications, drug therapy)
  • Magnetic Resonance Angiography
  • Prednisolone (administration & dosage)

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