A review of the pharmacology of carbonic anhydrase inhibitors for the treatment of glaucoma in dogs and cats.

Abstract

Glaucoma is a heterogeneous group of disorders usually associated with elevated intraocular pressure (IOP), leading to optic nerve damage, retinal ganglion cell death and irreversible vision loss. Therefore, medications that lower IOP are the mainstay of glaucoma therapy. Carbonic anhydrase inhibitors (CAIs) are some of the principal drugs used in the management of canine and feline glaucoma. This paper summarises current knowledge of the mechanism of action of these agents and their effect on IOP in dogs and cats. It also discusses potential harmful side effects of CAIs and presents current opinions about their role and place in the medical management of glaucoma in small animals.

• Authors: Tomasz Maślanka
• Journal: Veterinary journal (London, England : 1997) (Vet J) Vol. 203 Issue 3 Pg. 278-84 (Mar 2015) ISSN: 1532-2971 [Electronic] England
• PMID: 25660816 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.

Chemical References

• Carbonic Anhydrase Inhibitors

Topics

• Animals
• Carbonic Anhydrase Inhibitors (pharmacology, therapeutic use)
• Cat Diseases (drug therapy)
• Cats
• Dog Diseases (drug therapy)
• Dogs
• Glaucoma (drug therapy, veterinary)