Abstract | AIMS: SUBJECTS AND METHODS: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation ( IGE) scale and the parent's global evaluation ( PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4(th) week. RESULTS: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen. CONCLUSIONS: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.
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Authors | Arucha Treesirichod, Suthida Chaithirayanon, Nattakarn Wongjitrat, Pattra Wattanapan |
Journal | Indian journal of dermatology
(Indian J Dermatol)
2015 Jan-Feb
Vol. 60
Issue 1
Pg. 103
ISSN: 1998-3611 [Electronic] India |
PMID | 25657419
(Publication Type: Journal Article)
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