Abstract |
This study was designed to compare the therapeutic and residual efficacy for 1 month of three topical ectoparasiticides on mixed-bred dogs against the brown dog tick, Rhipicephalus sanguineus. Adult dogs (n = 32, 10.8-18.4 kg BW) were allocated to 4 groups (n = 8) and infested with 50 adult ticks on days -8, -2, 7, 14, 21, and 28. Within each group, dogs were treated topically on day 0 with a control solution (CS), Vectra 3D (DPP), Frontline Plus (FM), or K9 Advantix (IP). Ticks were enumerated on dogs 24 h after treatment and each subsequent tick infestation by in situ thumb count assessment without removal and at 48 h by combing and removal. Acaricidal efficacy was calculated using arithmetic means for all 24 and 48 h tick count assessments. From 42 to 56% of the total, infested ticks were found on dogs 48 h post-challenge in the CS group. Therapeutic efficacy for all treatments ranged from 45.5 to 64.6% after 48 h of infestation. Residual efficacy after FM treatment was consistently lower compared to DPP or IP treatments at the 24 h assessments on days 8, 22, 23, and 29. Residual efficacy measured at this last time point was 94.8% for DPP, 83.1% for IP, and 46.9% for FM. This study demonstrates that permethrin-based formulations (DPP and IP) provided a quicker onset of residual protection against brown dog ticks compared to FM. Although DPP and IP are both permethrin-based formulations, DPP exhibited consistently higher residual acaricidal efficacies and was the only treatment that provided >90% protection for 1 month at 24 h post challenge.
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Authors | Marie Varloud, Josephus J Fourie |
Journal | Parasitology research
(Parasitol Res)
Vol. 114
Issue 5
Pg. 1711-9
(May 2015)
ISSN: 1432-1955 [Electronic] Germany |
PMID | 25656465
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acaricides
- Pyrazoles
- Permethrin
- Methoprene
- fipronil
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Topics |
- Acaricides
(administration & dosage)
- Animals
- Dog Diseases
(drug therapy, parasitology, prevention & control)
- Dogs
- Female
- Hair
(parasitology)
- Male
- Methoprene
(administration & dosage)
- Permethrin
(administration & dosage)
- Pyrazoles
(administration & dosage)
- Random Allocation
- Rhipicephalus sanguineus
(physiology)
- Tick Infestations
(drug therapy, parasitology, prevention & control, veterinary)
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