Abstract |
Several studies have detected oestrogen and progesterone receptors in meningioma specimens; recently we have also confirmed the presence of steroid receptors in cultured cells from meningiomas. This paper describes the oestrogen and progesterone receptor assay in cultured cells from 6 meningiomas and the influence of steroid hormones on the cell growth and morphology. Four (66%) of the 6 specimens were positive for both receptors. Growth of cultured cells from tumours without receptors is not appreciably modified by the addition of hormones; the cultured cells from tumours with positive receptors are not essentially influenced by oestrogen, whereas progesterone produces a rapid and marked suppression of the cell growth and modifies their form and adhesivity; also the addition of an oestrogen and progesterone blend produces growth suppression. A similar effect of the progesterone on the cultured cells has also been obtained in a specimen of malignant meningioma. The results of this study suggest that the modulation of progesterone levels may be of therapeutic usefulness, particularly in patients with recurrent malignant meningiomas.
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Authors | F Maiuri, S Montagnani, B Gallicchio, M Carandente, G G Lanza, F D'Andrea |
Journal | Neurological research
(Neurol Res)
Vol. 11
Issue 1
Pg. 9-13
(Mar 1989)
ISSN: 0161-6412 [Print] England |
PMID | 2565555
(Publication Type: Journal Article)
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Chemical References |
- Estrogens
- Receptors, Estrogen
- Receptors, Progesterone
- Progesterone
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Topics |
- Aged
- Cell Division
(drug effects)
- Estrogens
(pharmacology)
- Female
- Humans
- Male
- Meningeal Neoplasms
(metabolism)
- Meningioma
(metabolism)
- Middle Aged
- Progesterone
(pharmacology)
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
- Tumor Cells, Cultured
(cytology, drug effects, metabolism)
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