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Oestrogen and progesterone sensitivity in cultured meningioma cells.

Abstract
Several studies have detected oestrogen and progesterone receptors in meningioma specimens; recently we have also confirmed the presence of steroid receptors in cultured cells from meningiomas. This paper describes the oestrogen and progesterone receptor assay in cultured cells from 6 meningiomas and the influence of steroid hormones on the cell growth and morphology. Four (66%) of the 6 specimens were positive for both receptors. Growth of cultured cells from tumours without receptors is not appreciably modified by the addition of hormones; the cultured cells from tumours with positive receptors are not essentially influenced by oestrogen, whereas progesterone produces a rapid and marked suppression of the cell growth and modifies their form and adhesivity; also the addition of an oestrogen and progesterone blend produces growth suppression. A similar effect of the progesterone on the cultured cells has also been obtained in a specimen of malignant meningioma. The results of this study suggest that the modulation of progesterone levels may be of therapeutic usefulness, particularly in patients with recurrent malignant meningiomas.
AuthorsF Maiuri, S Montagnani, B Gallicchio, M Carandente, G G Lanza, F D'Andrea
JournalNeurological research (Neurol Res) Vol. 11 Issue 1 Pg. 9-13 (Mar 1989) ISSN: 0161-6412 [Print] England
PMID2565555 (Publication Type: Journal Article)
Chemical References
  • Estrogens
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Progesterone
Topics
  • Aged
  • Cell Division (drug effects)
  • Estrogens (pharmacology)
  • Female
  • Humans
  • Male
  • Meningeal Neoplasms (metabolism)
  • Meningioma (metabolism)
  • Middle Aged
  • Progesterone (pharmacology)
  • Receptors, Estrogen (metabolism)
  • Receptors, Progesterone (metabolism)
  • Tumor Cells, Cultured (cytology, drug effects, metabolism)

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