Effect of pretransplant hepatitis C virus on the development of new-onset diabetes mellitus after transplant in Egyptian living-donor renal allotransplant recipients at Mansoura Urology and Nephrology Center.

Abstract

OBJECTIVES:

New-onset diabetes mellitus after transplant is a common complication in renal allograft recipients. Recently, a high prevalence of diabetes mellitus has been reported in patients with chronic hepatitis C virus. The association between hepatitis C and diabetes mellitus is well demonstrated in the general population, but some controversy still exists. This work aimed to study the effect of pretransplant hepatitis C virus on the development of new-onset diabetes mellitus after transplant in Egyptian living-donor renal allotransplant recipients.

MATERIALS AND METHODS:

This retrospective single center study included 913 kidney transplant recipients who were transplanted at Mansoura Urology and Nephrology Center between 2000 and 2010. The patients were divided into 4 groups according to their hepatitis C virus serology and diabetic status.

RESULTS:

Pretransplant dialysis duration and number of blood transfusion units were statistically significant among both viremic and nonviremic groups. With respect to induction therapy, a highly statistical significance was observed between the 4 groups regarding presence and type of adjuvant therapy (P < .001). With respect to maintenance immunosuppression, high statistically significant results were observed regarding steroid and rapamycin between the 4 groups (P < .001) with lower significance regarding mycophenolate mofetil (P = .04) but no significance regarding azathioprine, cyclosporine, or tacrolimus therapy. Incidence of new-onset diabetes mellitus after transplant was statistically higher in the viremic than nonviremic group (P < .001).

CONCLUSIONS:

There was a positive correlation between incidence of new-onset diabetes mellitus after transplant and positive pretransplant hepatitis C virus status.

• Authors: Mohamed H Abbas, Mabrouk I Ismail, Salem A El Deeb, Ayman M Nagib, Nabil M Hassan, Ayman F Refaie, Hanzada M El Maghrabi, Ahmed A Denewar, Mohamed A Bakr
• Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 13 Issue 1 Pg. 26-34 (Feb 2015) ISSN: 2146-8427 [Electronic] Turkey
• PMID: 25654411 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Immunosuppressive Agents

Topics

• Adolescent
• Adult
• Biomarkers (blood)
• Diabetes Mellitus (blood, diagnosis, etiology, virology)
• Egypt
• Female
• Graft Survival
• Hepacivirus (pathogenicity)
• Hepatitis C (blood, complications, diagnosis, virology)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Kidney Failure, Chronic (complications, diagnosis, surgery)
• Kidney Transplantation (adverse effects)
• Living Donors
• Male
• Middle Aged
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Time Factors
• Treatment Outcome
• Young Adult