Class A1 scavenger receptors in cardiovascular diseases.

Abstract

Class A1 scavenger receptors (SR-A1) are membrane glycoproteins that can form homotrimers. This receptor was originally defined by its ability to mediate the accumulation of lipids in macrophages. Subsequent studies reveal that SR-A1 plays critical roles in innate immunity, cell apoptosis and proliferation. This review highlights recent advances in understanding the structure, receptor pathway and regulation of SR-A1. Although its role in atherosclerosis is disputable, recent discoveries suggest that SR-A1 function in anti-inflammatory responses by promoting an M2 macrophage phenotype in cardiovascular diseases. Therefore, SR-A1 may be a potential target for therapeutic intervention of cardiovascular diseases.

• Authors: Jingjing Ben, Xudong Zhu, Hanwen Zhang, Qi Chen
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 172 Issue 23 Pg. 5523-30 (Dec 2015) ISSN: 1476-5381 [Electronic] England
• PMID: 25651870 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2015 The British Pharmacological Society.

Chemical References

• Scavenger Receptors, Class A

Topics

• Animals
• Cardiovascular Diseases (drug therapy, metabolism)
• Humans
• Scavenger Receptors, Class A (agonists, chemistry, metabolism)