Association of HLA-DR/DQ polymorphism with Alzheimer's disease.

Abstract

BACKGROUND:

Alzheimer's disease (AD) is a complex disorder, resulting from an interaction between environmental and genetic factors. Several studies have addressed the association of AD with major histocompatibility complex (MHC) polymorphisms without arriving at any definite conclusions. The human leukocyte antigen (HLA) region is the key susceptibility locus in many immunological diseases. The aim of this study was to investigate the probable association between HLA-DR/DQ alleles and AD in Tunisian patients.

METHODS:

HLA-DR/DQ genotyping was performed using polymerase chain reaction sequence-specific primers with 55 AD patients and 100 healthy individuals serving as the control group.

RESULTS:

AD in Tunisian patients was found to be associated with the following alleles (Pc denotes Bonferroni corrected probability values): HLA-DRB1*15 (Pc < 10-3), DRB1*04 (Pc = 0.03) and DQB1*06 (Pc < 10-3). Two haplotypes found to be associated with the disease were DRB1*1501/DQB1*0602 (Pc < 10-3) and DRB1*0402/DQB1*0302 (Pc = 0.02).

CONCLUSIONS:

The authors believe this to be the first research linking the haplotypes DRB1*1501/DQB1*0602 and DRB1*04/DQB1*0302 with AD. Larger studies in other populations will be important to support the present findings of the possible susceptible risk of HLA-DR/DQ in AD.

• Authors: Leila Mansouri, Mariem Messalmani, Sarra Klai, Ines Bedoui, Hajer Derbali, Nasreddine Gritli, Ridha Mrissa, Najiba Fekih-Mrissa
• Journal: The American journal of the medical sciences (Am J Med Sci) Vol. 349 Issue 4 Pg. 334-7 (Apr 2015) ISSN: 1538-2990 [Electronic] United States
• PMID: 25651370 (Publication Type: Journal Article)

Chemical References

• HLA-DQ Antigens
• HLA-DQ beta-Chains
• HLA-DQB1 antigen
• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Aged
• Aged, 80 and over
• Alleles
• Alzheimer Disease (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease (genetics)
• Genotype
• HLA-DQ Antigens (genetics)
• HLA-DQ beta-Chains (genetics)
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains (genetics)
• Haplotypes (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)