Abstract | CONCLUSION: This study demonstrated that the common immunological mechanism, which involves aberration of immunoglobulin and T-cell distribution in histologically distinctive tonsils, may be associated with the pathogenesis of tonsillar focal infection. OBJECTIVES: Tonsillar focal infection comprises a group of relatively common diseases combined with chronic tonsillar infection, is associated with unusual immune responses in tonsils, and may cause lesions in another distant target organ. This study aimed to investigate the distribution of inflammatory T cells and T-cell regulatory elements, such as programmed cell death-1 (PD-1) and Fork head box protein 3 (Foxp3), immunoglobulin production, and histological characteristics in tonsils from patients with tonsillar focal infection. METHODS: RESULTS: The overexpression of CD8(+) T cells combined with decreased expression of Foxp3 and PD-1 and the aberration of immunoglobulin production, which may be due to the elevated expression of activation-induced deaminase (AID), B-cell-activating factor of the TNF family (BAFF), supporting isotype switching, and B-cell survival in the histologically distinctive tonsils.
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Authors | Hong-Xue Meng, Rintaro Ohe, Hui-ning Li, Su-ran Yang, Takanobu Kabasawa, Tomoya Kato, Lei Zhang, Hiroya Ohtake, Akihiro Ishida, Nobuo Ohta, Xiao-ming Jin, Seiji Kakehata, Mitsunori Yamakawa |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 135
Issue 3
Pg. 264-70
(Mar 2015)
ISSN: 1651-2251 [Electronic] England |
PMID | 25649885
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- B-Cell Activating Factor
- CD8 Antigens
- FDCSP protein, human
- FOXP3 protein, human
- Forkhead Transcription Factors
- Immunoglobulins
- PDCD1 protein, human
- Programmed Cell Death 1 Receptor
- Proteins
- SDC1 protein, human
- Syndecan-1
- TNFSF13B protein, human
- AICDA (activation-induced cytidine deaminase)
- Cytidine Deaminase
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Topics |
- Adult
- Arthritis, Rheumatoid
(immunology, metabolism)
- B-Cell Activating Factor
(metabolism)
- CD8 Antigens
(metabolism)
- CD8-Positive T-Lymphocytes
(physiology)
- Cellular Microenvironment
- Cytidine Deaminase
(metabolism)
- Female
- Focal Infection
(immunology, metabolism, pathology)
- Forkhead Transcription Factors
(metabolism)
- Glomerulonephritis, IGA
(immunology, metabolism)
- Humans
- Immunoglobulins
(metabolism)
- Male
- Middle Aged
- Palatine Tonsil
(pathology)
- Programmed Cell Death 1 Receptor
(metabolism)
- Proteins
(metabolism)
- Syndecan-1
(metabolism)
- Tonsillitis
(immunology, metabolism, pathology)
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