Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.

Abstract

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

• Authors: Stefania Ordanini, Norbert Varga, Vanessa Porkolab, Michel Thépaut, Laura Belvisi, Andrea Bertaglia, Alessandro Palmioli, Angela Berzi, Daria Trabattoni, Mario Clerici, Franck Fieschi, Anna Bernardi
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 18 Pg. 3816-9 (Mar 04 2015) ISSN: 1364-548X [Electronic] England
• PMID: 25648900 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cell Adhesion Molecules
• DC-specific ICAM-3 grabbing nonintegrin
• Dendrimers
• Lectins, C-Type
• Ligands
• Receptors, Cell Surface
• Serum Albumin
• mannose-bovine serum albumin conjugate
• Mannose

Topics

• CD4-Positive T-Lymphocytes (drug effects, virology)
• Cell Adhesion Molecules (antagonists & inhibitors, chemistry, genetics)
• Cell Line
• Cells, Cultured
• Dendrimers (chemistry, pharmacology)
• HIV Infections (prevention & control)
• HIV-1 (pathogenicity)
• Humans
• Lectins, C-Type (antagonists & inhibitors, chemistry, genetics)
• Ligands
• Mannose (chemistry)
• Receptors, Cell Surface (antagonists & inhibitors, chemistry, genetics)
• Serum Albumin (chemistry)