Abstract | BACKGROUND: After the onset of HAART, some HIV-infected individuals under treatment present a exacerbated inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory syndrome (IRIS). Few reports of tegumentary leishmaniasis have been described in association with IRIS. Moreover, the immunopathogenesis of IRIS in association with Leishmania is unclear. CASE PRESENTATION: CONCLUSION: The results suggest that the production of inflammatory cytokines by unstimulated T-lymphocytes could contribute to occurrence of leishmaniasis associated with IRIS.
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Authors | Luana Gois, Roberto Badaró, Robert Schooley, Maria Fernanda Rios Grassi |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 15
Pg. 38
(Feb 03 2015)
ISSN: 1471-2334 [Electronic] England |
PMID | 25645330
(Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- AIDS-Related Opportunistic Infections
(complications, diagnosis)
- Adult
- Antigens, Protozoan
(blood)
- Antiretroviral Therapy, Highly Active
- Diagnosis, Differential
- Humans
- Immune Reconstitution Inflammatory Syndrome
(complications, diagnosis)
- Leishmania
(immunology)
- Leishmaniasis, Mucocutaneous
(complications, diagnosis)
- Male
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