Abstract | BACKGROUND: Drug resistance is a major obstacle for the efficacy of chemotherapeutic treatment of tumors. Oct-3/4, a self-renewal regulator in stem cells, is expressed in various kinds of solid tumors including glioblastoma. Although Oct-3/4 expression has been implicated in the malignancy and prognosis of glioblastomas, little is known of its involvement in drug resistances of glioblastoma. METHODS: RESULTS: CONCLUSION: GENERAL SIGNIFICANCE: If the drug-resistance of glioblastoma cells could be suppressed, it should be a highly ameliorative treatment for glioblastoma patients. Therefore, signaling pathways from Oct-3/4 to ATP binding cassette transporter G2 should be intensively elucidated to develop new therapeutic interventions for better efficacy of anti- cancer drugs.
|
Authors | Yuki Hosokawa, Hisaaki Takahashi, Akihiro Inoue, Yuya Kawabe, Yu Funahashi, Kenji Kameda, Kana Sugimoto, Hajime Yano, Hironobu Harada, Shohei Kohno, Shiro Ohue, Takanori Ohnishi, Junya Tanaka |
Journal | Biochimica et biophysica acta
(Biochim Biophys Acta)
Vol. 1850
Issue 6
Pg. 1197-205
(Jun 2015)
ISSN: 0006-3002 [Print] Netherlands |
PMID | 25644290
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- ABCG2 protein, human
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
- Antimetabolites, Antineoplastic
- Neoplasm Proteins
- Octamer Transcription Factor-3
- POU5F1 protein, human
- Doxorubicin
- L-Lactate Dehydrogenase
- Poly(ADP-ribose) Polymerases
|
Topics |
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
(metabolism)
- Animals
- Antimetabolites, Antineoplastic
(metabolism, pharmacology)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Dose-Response Relationship, Drug
- Doxorubicin
(metabolism, pharmacology)
- Drug Resistance, Neoplasm
(genetics)
- Glioblastoma
(drug therapy, genetics, metabolism, pathology)
- Humans
- L-Lactate Dehydrogenase
(metabolism)
- Male
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Proteins
(metabolism)
- Octamer Transcription Factor-3
(genetics, metabolism)
- Phenotype
- Poly(ADP-ribose) Polymerases
(metabolism)
- RNA Interference
- Signal Transduction
- Time Factors
- Transfection
- Tumor Burden
(drug effects)
|