Abstract | BACKGROUND: FINDINGS: In this study, forty-nine additional osteosarcoma samples from 14 individual patients were assessed for GD2 expression via immunohistochemistry, of which 47 samples were found to express GD2. In matched samples from patients, GD2 expression seen at initial biopsy was found to persist in 100% of tissues taken at recurrence. CONCLUSIONS: GD2 expression was found to persist upon recurrence. These results suggest a phase 2 trial in children with recurrent osteosarcoma should provide an appropriate read out on the efficacy of anti-GD2 antibody.
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Authors | Vincent I Poon, Michael Roth, Sajida Piperdi, David Geller, Jonathan Gill, Erin R Rudzinski, Douglas S Hawkins, Richard Gorlick |
Journal | Clinical sarcoma research
(Clin Sarcoma Res)
Vol. 5
Issue 1
Pg. 4
( 2015)
ISSN: 2045-3329 [Print] England |
PMID | 25642322
(Publication Type: Journal Article)
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