Abstract |
Monodisperse, ultrasmall (<5 nm) Cu(2-x)S nanodots (u-Cu(2-x)S NDs) with significantly strong near-infrared absorption and conversion are successfully demonstrated for effective deep-tissue photoacoustic imaging-guided photothermal therapy both in vitro and in vivo. Owing to ultrasmall nanoparticle size and high water dispersibility as well as long stability, such nanodots possess a prolonged circulation in blood and good passive accumulation within tumors through the enhanced permeability and retention effect. These u-Cu(2-x)S NDs have negligible side effects to both blood and normal tissues according to in vivo toxicity evaluations for up to 3 months, showing excellent hemo/histocompatibility. Furthermore, these u-Cu(2-x)S NDs can be thoroughly cleared through feces and urine within 5 days, showing high biosafety for further potential clinical translation. This novel photoacoustic imaging-guided photothermal therapy based on u-Cu(2-x)S NDs composed of a single component shows great prospects as a multifunctional nanoplatform with integration and multifunction for cancer diagnosis and therapy.
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Authors | Juan Mou, Pei Li, Chengbo Liu, Huixiong Xu, Liang Song, Jin Wang, Kun Zhang, Yu Chen, Jianlin Shi, Hangrong Chen |
Journal | Small (Weinheim an der Bergstrasse, Germany)
(Small)
Vol. 11
Issue 19
Pg. 2275-83
(May 20 2015)
ISSN: 1613-6829 [Electronic] Germany |
PMID | 25641784
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
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Topics |
- Animals
- Cell Survival
(drug effects)
- Copper
(chemistry)
- Diagnostic Imaging
- Female
- HeLa Cells
- Humans
- Hyperthermia, Induced
- Imaging, Three-Dimensional
- Metabolic Networks and Pathways
(drug effects)
- Mice, Nude
- Nanoparticles
(chemistry, toxicity, ultrastructure)
- Particle Size
- Photoacoustic Techniques
(methods)
- Phototherapy
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