PNPLA3 polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis.

Abstract

BACKGROUND AND AIM:

One single-nucleotide polymorphisms (SNPs) rs738409 in the patatin-like phospholipase domain-containing 3 gene (PNPLA3) has been implicated in susceptibility to non-alcoholic fatty liver disease (NAFLD) across different populations. One meta-analysis confirmed this association, but within it, only two Asian studies were included. This meta-analysis aimed to investigate the association in Asian population.

METHODS:

All eligible case-control studies were identified by searching through PubMed and Chinese language databases (CNKI and WanFang) up to July 1, 2014. Pooled estimates (odds ratio [OR] and standardized mean difference) were used to assess the strength of associations in fixed or random-effects models.

RESULTS:

A total of 12 studies with 4495 cases and 7431 controls were included. SNP rs738409 G allele was confirmed as a risk factor for NAFLD (G allele vs C allele: OR = 1.92, 95% confidence interval [95%CI]: 1.54-2.39). In addition, based on studies with certain clinical measurements data, G allele carriers were more likely to have higher level of serum alanine aminotransferase (ALT) (standard mean difference [SMD] = 7.03, 95% CI: 2.47-11.60), and higher fibrosis score (SMD = 0.39, 95% CI: 0.18-0.60).

CONCLUSION:

This study provided evidence of SNP rs738409 G allele as a strong risk factor of NAFLD susceptibility and higher level of serum ALT in Asian population.

• Authors: Long Zhang, Wei You, Hanze Zhang, Rui Peng, Qin Zhu, Aihua Yao, Xiangcheng Li, Yebin Zhou, Xuehao Wang, Liyong Pu, Jindao Wu
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 30 Issue 5 Pg. 821-9 (May 2015) ISSN: 1440-1746 [Electronic] Australia
• PMID: 25641744 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

Chemical References

• Membrane Proteins
• Alanine Transaminase
• Lipase
• adiponutrin, human

Topics

• Alanine Transaminase (blood)
• Alleles
• Asian People (genetics)
• Case-Control Studies
• Databases, Bibliographic
• Fibrosis
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Humans
• Lipase (genetics)
• Liver (pathology)
• Membrane Proteins (genetics)
• Non-alcoholic Fatty Liver Disease (genetics, pathology)
• Phenotype
• Polymorphism, Single Nucleotide (genetics)
• Risk
• Risk Factors