Abstract | OBJECTIVES:
Methamphetamine abuse affects brain structure and function. Although methamphetamine and cannabis are commonly abused together, few studies have investigated the differential neurocognitive consequences of methamphetamine abuse with or without cannabis. Furthermore, the effects of drug use on the developing adolescent brain remain poorly understood. We compared neurocognitive function between adolescents with 'pure' methamphetamine abuse, those with comorbid methamphetamine and cannabis abuse, and healthy controls at baseline and follow-up. METHODS: Individuals residing in the greater Cape Town region, between the ages of 13 and 18 years, were recruited into either Methamphetamine only group (Meth-only; n=10), Methamphetamine and cannabis group (Meth-cann; n=10) or healthy control (n=20) groups using a quasi-experimental design. All participants underwent a comprehensive neurocognitive assessment. Substance-use variables and psychiatric symptom counts were also recorded. A portion of the Meth-only and control participants completed 12-month follow-up assessments. RESULTS: While the Meth-cann group demonstrated widespread neurocognitive deficits at baseline, these deficits were restricted to the self-monitoring domain in the Meth-only group at baseline and at follow-up. CONCLUSIONS:
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Authors | Natalie L Cuzen, Sheri-Michelle Koopowitz, Helen L Ferrett, Dan J Stein, Deborah Yurgelun-Todd |
Journal | BMJ open
(BMJ Open)
Vol. 5
Issue 1
Pg. e005833
(Jan 30 2015)
ISSN: 2044-6055 [Electronic] England |
PMID | 25636791
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. |
Topics |
- Adolescent
- Adolescent Behavior
- Amphetamine-Related Disorders
(epidemiology)
- Cognition Disorders
(epidemiology)
- Comorbidity
- Female
- Follow-Up Studies
- Humans
- Male
- Marijuana Abuse
(epidemiology)
- Neuropsychological Tests
- South Africa
(epidemiology)
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