Comparison of the KIR3DS1/Bw4 distribution in Chinese healthy and acute myeloid leukemia individuals.

Abstract

Killer cell immunoglobulin like receptor (KIR) 3DS1 is one of the most important activating receptors and some studies revealed that KIR3DS1 combined with HLA ligand was not related to acute myeloid leukemia (AML), but rare data was reported in Chinese population. In this study, KIR3DS1 gene polymorphisms and HLA-Bw4 were investigated in 189 Chinese AML patients compared with 166 healthy individuals. The results showed that the distributions of KIR3DS1, Bw4, 3DS1/Bw4 and 3DS1/Bw4-80I were insignificantly different between AML and healthy individuals. This study suggests that the presence of 3DS1 and HLA-Bw4 ligands have no effect on AML disease.

• Authors: Sudan Tao, Yanmin He, Wei Zhang, Wei Wang, Junjun He, Zhedong Han, Nanying Chen, Lina Dong, Ji He, Faming Zhu, Hangjun Lv
• Journal: Human immunology (Hum Immunol) Vol. 76 Issue 2-3 Pg. 79-82 (Mar 2015) ISSN: 1879-1166 [Electronic] United States
• PMID: 25636577 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Chemical References

• HLA-B Antigens
• HLA-Bw4 antigen
• Receptors, KIR3DS1

Topics

• Aged
• China
• DNA Mutational Analysis
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• HLA-B Antigens (genetics, metabolism)
• Humans
• Killer Cells, Natural (immunology)
• Leukemia, Myeloid, Acute (genetics, immunology)
• Polymorphism, Genetic
• Protein Binding (genetics)
• Receptors, KIR3DS1 (genetics, metabolism)