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Urea for hyponatremia?

Abstract
Once the standard of care for cerebral edema, urea can also be used to treat hyponatremia. The 2014 European Clinical Practice Guidelines recommend urea for the treatment of the syndrome of inappropriate antidiuretic hormone, while discouraging use of vasopressin antagonists. Although there is evidence that urea can diminish hypertonic injury to brain cells caused by rapid correction of hyponatremia, clinical trials are needed that include patients at high risk to develop complications from overcorrection.
AuthorsRichard H Sterns, Stephen M Silver, John K Hix
JournalKidney international (Kidney Int) Vol. 87 Issue 2 Pg. 268-70 (Feb 2015) ISSN: 1523-1755 [Electronic] United States
PMID25635717 (Publication Type: Journal Article, Comment)
Chemical References
  • Urea
Topics
  • Animals
  • Hyponatremia (drug therapy)
  • Male
  • Urea (therapeutic use)

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