Abstract | BACKGROUND: METHODS: RESULTS: The contents of VEGF in pleural effusion and serum of patients with malignant hydrothorax were (384.91 ± 120.18), and (129.62 ± 46.35) ng/L, respectively, which were significantly higher than those of the patients with benign hydrothorax (207.97 ± 64.04), (63.49 ± 24.58) ng/L (P < 0.01). The sensitivity and specificity of detecting VEGF in pleural effusion were 80.0% and 96.7% (the boundary value was 297.06 ng/L), respectively for diagnosing benign and malignant hydrothorax. The sensitivity and specificity of serum were 74.3% and 96.7%, respectively (the boundary value was 99.21 ng/L) for diagnosing benign and malignant hydrothorax. The diagnostic efficiencies of EGFR and VEGF in hydrothorax were similar. There was a significant correlation between EGFR and VEGF in hydrothorax (P < 0.01). CONCLUSIONS:
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Authors | Yan Gu, Min Zhang, Guo-Hua Li, Jun-Zhen Gao, Liping Guo, Xiao-Juan Qiao, Li-Hong Wang, Lan He, Mei-Ling Wang, Li Yan, Xiu-Hua Fu |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 128
Issue 3
Pg. 305-9
(Feb 05 2015)
ISSN: 2542-5641 [Electronic] China |
PMID | 25635424
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vascular Endothelial Growth Factor A
- ErbB Receptors
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Topics |
- Adult
- Enzyme-Linked Immunosorbent Assay
- ErbB Receptors
(blood)
- Female
- Gene Dosage
(genetics)
- Humans
- Hydrothorax
(blood)
- In Situ Hybridization, Fluorescence
- Male
- Middle Aged
- Pleural Effusion
(blood)
- Vascular Endothelial Growth Factor A
(blood)
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