Association between methylation of SHP-1 isoform I and SSTR2A promoter regions with breast and prostate carcinoma development.

Abstract

Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 in breast cancer. We found significant concordances for both cancers and SHP-1(I) unmethylation, and increased HER2 expression and SSTR2A methylation in breast cancer. Moreover, we found a correlation between methylation patterns of two genes in normal breast tissue. These data might assist to select subgroups of patients for the administration of alternative therapies.

• Authors: María Mercedes Tiscornia, Heidi Soledad González, María Angélica Lorenzati, Pedro Darío Zapata
• Journal: Cancer investigation (Cancer Invest) Vol. 33 Issue 3 Pg. 61-9 (Mar 2015) ISSN: 1532-4192 [Electronic] England
• PMID: 25635370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Protein Isoforms
• Receptors, Somatostatin
• somatostatin receptor 2
• PTPN6 protein, human
• Protein Tyrosine Phosphatase, Non-Receptor Type 6

Topics

• Aged
• Biomarkers, Tumor (genetics)
• Breast Neoplasms (genetics, metabolism, pathology)
• DNA Methylation
• Female
• Humans
• Male
• Middle Aged
• Promoter Regions, Genetic
• Prostatic Neoplasms (genetics, metabolism, pathology)
• Protein Isoforms
• Protein Tyrosine Phosphatase, Non-Receptor Type 6 (genetics)
• Receptors, Somatostatin (genetics, metabolism)