[Sulfasalazine therapy in spondylarthritis ankylopoietica].

Abstract

In the past few years several reports have been published on the favourable effect of sulphasalazine in ankylosing spondylitis. This induced us to compare sulphasalazine with placebo in a prospective, randomized single-blind trial in 63 patients with active ankylosing spondylitis. After termination of the 24 week course of treatment significant improvement was registered in several clinical parameters both in the group taking the active drug (31 patients) and in that on placebo (32 patients). The advantage of sulphasalazine over placebo only proved to be significant in the duration of articular morning stiffness and in reducing disturbances of sleep. Observations claiming sulphasalazine to act as a remission inducing drug for ankylosing spondylitis have neither been confirmed nor ruled out by our experiences. Accurate appraisal of the effectiveness of sulphasalazine still calls for further extensive placebo-controlled double-blind studies.

• Authors: V Winkler
• Journal: Orvosi hetilap (Orv Hetil) Vol. 130 Issue 2 Pg. 77-81 (Jan 08 1989) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Sulphasalazin kezelés spondylarthritis ankylopoeticában.
• PMID: 2563308 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Review)

Chemical References

• Placebos
• Sulfasalazine

Topics

• Adult
• Clinical Trials as Topic
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Placebos
• Spondylitis, Ankylosing (drug therapy)
• Sulfasalazine (therapeutic use)